Terlipressin

Asia Bio-Pharmaceutical Research Institute

Terlipressin

Product name:Terlipressin
CAS: 14636-12-5
Molecular Formula: C52H74N16O15S2
Molecular Weight: 1227.37
Product description:A new type of synthetic long-acting vasopressin preparations, chemical name three ammonia acyl lysine vasopressin, belongs to a kind of precursor drugs, itself is inactive, the body through the aminopeptidase, take off the ends of their N 3 after ammonia acyl residues, slow 'release' of a reactive lysine vasopressin. It is this 'slow release' mechanism, make its can maintain smooth muscle contraction after a drug for 10 hours, and equivalent dose vasopressin, its active only for 20 to 40 minutes. Slowly, on the other hand, due to the enzyme solution cycle of lysine vasopressin reach toxic levels, therefore, the use of vasopressin is safe. The pharmacological effects of vasopressin is splanchnic vascular smooth muscle contraction, reduces splanchnic blood flow (e.g., reduce the mesenteric, splenic, blood flow to the uterus, etc), thus reducing the portal vein blood flow, reduce portal vein pressure.

 

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