Product name:Everolimus
CAS: 159351-69-6
Molecular Formula: C53H83NO14
Molecular Weight: 958.2244
Product description:Cell communication, belongs to the interference to prevent the growth of the tumour cell kinase, a class of drugs is a kind of oral mammals rapamycin (mTOR) inhibitor, in the past are mainly used for clinical prevention of rejection after kidney transplantation and heart transplants. Now also can be used in the treatment has been used two kinds of inhibition of vascular endothelial growth factor receptor kinase inhibitors: chougny for ni (Sutent, Pfizer) and sorafenib (Nexavar, bayer) in patients with advanced kidney cancer, and have less side effects. Chougny for and sorafenib is a kinase inhibitor (role in a variety of targeted cells), and in accordance with the dimension of therapy is to block mammals, the target of rapamycin (mTOR) specific proteins, cancer cell growth, differentiation and metabolism. The mTOR pathway dysregulation in some tumors. According to the dimension of therapy combined with intracellular protein FKBP - 12, inhibition of complex formation, thus inhibiting mTOR kinase activity, at the same time, reduce the mTOR downstream effector S6 ribosomal protein kinase (S6K1) and eukaryotic