Product name:Crizotinib
CAS: 877399-52-5
Molecular Formula: C21H22Cl2FN5O
Molecular Weight: 450.343
Product description:The azole resistance often occurs in g 1 year for his medical treatment. About one-third of patients with drug resistance is made up of ALK tyrosine kinase gene mutation or ALK gene amplification. Color red is for the second generation of oral ALK a tyrosine kinase inhibitors, it is not applied to MET proto-oncogene, but the inhibition of the insulin-like growth factor 1 receptor. In preclinical models, the color red for inhibiting ALK anti-tumor effect is g azole for 20 times. The study found that the color red for, for, tolerance of grams of the central nervous system lesions in NSCLC have same reaction. The color red for, for the grams of the NSCLC patients treated for his median progression-free surial was 6.9 months, and for use in patients without grams of thiazole for his treatment median progression-free surial was 10.4 months. Carries on the preliminary molecular analysis found that for some patients, regardless of the color red is for resistance mechanism of ALK dependence or the ALK dependency, it is for the majority of patients have clinical benefit.