Product name:Rat inducible nitric oxide synthase,iNOS ELISA KIT
Description:
NO is produced by a group of enzymes called nitric oxide synthases (NOS). These enzymes catalyze the production of NO and L-citrulline from L-arginine, O2, and NADPH-derived electrons. Mammalian systems contain three well-characterized isoforms of the enzyme: neuronal NOS (nNOS, also called NOS1), inducible NOS (iNOS or NOS2), and endothelial NOS (eNOS or NOS3). They all require a number of cofactors and prosthetic groups for activity including FAD, FMN,heme, calmodulin, and tetrahydrobiopterin. The homodimeric form is required for NO production, and the subunits have molecular masses of approximately 160 kDa (nNOS), 135 kDa (eNOS), and 130 kDa (iNOS). Three distinct domains are necessary for catalytic activity.