Product name:Rat E-Selectin ELISA kit
Description:
E selectin is a type I membrane protein that belongs to the selectin family of surface molecules (along with CD62L and CD62P). Selectins are C type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium.E selectin is an endothelial cell specific selectin that is expressed on cytokine induced endothelial cells only after activation with proinflammatory cytokines. In vitro experiments have shown that IL1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of CD62E in an NFkB dependent signalling cascade. E selectin has been associated with blood vessel endothelium in diverse inflammatory situations. The main ligands recognised by E selectin are oligosaccharides related to sialyl lewis x.