Product name:Human TGF-β1 ELISA Kit
Description:
TGF-β is capable of producing a variety of effects and virtually all cell types respond to this factor in some way. The inappropriate presence of active TGF-β1 has been implicated in a variety of pathological conditions.This complex consists of TGF-β1 associated non-covalently with a protein designated the latency associated peptide (LAP). TGF-β1 and LAP represent components of a pro-peptide that is cleaved in a post-golgi compartment prior to secretion. LAP and TGF-β1 each consist of a disulfide-linked homodimer and the association of these two components renders TGF-β1 inactive and inaccessible to anti-TGF-β antibodies.The mechanisms by which active TGF-β1 is released from these latent complexes represent important control steps for the regulation of the numerous effects of TGF-β1. Despite considerable study, these mechanisms are not well understood.