Product name:Human soluble Tumor Necrosis Factorαreceptor ELISA Kit
Description:
Tumor necrosis factor-α (TNFα) is a cytokine involved in regulation of the whole-body carbohydrate and lipid metabolism. One of the main metabolic effects of TNFα action is the development of insulin resistance.Two cell surface TNFα receptors were described in humans, TNFR1 (p60) and TNFR2 (p80), soluble forms of those receptors (sTNFR1 and sTNFR2) are present in plasma and it is supposed that their concentrations, especially sTNFR2, might reflect local action of TNFα in tissues. Soluble TNFR might neutralize TNFα at high levels, but they also might stabilize its bioactivity, help sequester TNFα to its membrane receptors and thus increase the effects of the cytokine.