Product name:Human NHE3 ELISA Kit
Description:
Na+/H+ exchangers-1–8 (also designated NHE-1–8 or Na+/H+ antiporters) are integral membrane proteins that are expressed in most mammalian tissues, where they regulate intracellular pH and cell volume. NHEs mediate the transport of hydrogen (H+) ions out of cells in exchange for extracellular sodium (Na+) ions. While NHE-1 is ubiquitously expressed, the NHE isoforms 2-8 have distinct tissue- and cell type-dependent expression and inhibitory characteristics.
Sodium / Hydrogen Exchanger 3 localizes to the apical membrane of renal proximal tubules where it is responsible for most of the sodium transport and fluid reabsorption. It translocates to internal pools where it mediates natriuresis when blood pressure increases abruptly. Sodium / Hydrogen Exchanger 3 is also expressed in the stomach and functions to protect the mucosa by secreting protons that diffuse into the mucous cells.