Human E-Cad ELISA Kit

Asia Bio-Pharmaceutical Research Institute

Human E-Cad ELISA Kit

Product name:Human E-Cad ELISA Kit
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E-cadherins are found in epithelial tissue, N-cadherins are found in neurons, and P-cadherins are  found in the placenta. E-cadherin (epithelial) is the most well-studied member of the family. It  consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain,  and an intracellular domain that binds p120-catenin and beta-catenin. The intracellular domain  contains a highly-phosphorylated region vital to beta-catenin binding and therefore to E-cadherin  function.E-cadherin downregulation decreases the strength of cellular adhesion within a tissue,  resulting in an increase in cellular motility. This in turn may allow cancer cells to cross the  basement membrane and invade surrounding tissues. E-cadherin is also used by pathologists to  diagnose different kinds of breast cancer. When compared with invasive duct carcinoma.

 

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