Human CD95 ELISA Kit

Asia Bio-Pharmaceutical Research Institute

Human CD95 ELISA Kit

Product name:Human CD95 ELISA Kit
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CD95 is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has  been shown to play a central role in the physiological regulation of programmed cell death, and  has been implicated in the pathogenesis of various malignancies and diseases of the immune system.  The interaction of this receptor with its ligand allows the formation of a death-inducing  signaling complex that includes Fas-associated death domain protein, caspase 8, and caspase 10.  The autoproteolytic processing of the caspases in the complex triggers a downstream caspase  cascade, and leads to apoptosis. CD95 has been also shown to activate NF-kappaB, MAPK3/ERK1, and  MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid  fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven  distinct isoforms have been described.

 

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