Human BMPR-ⅡELISA Kit

Asia Bio-Pharmaceutical Research Institute

Human BMPR-ⅡELISA Kit

Product name:Human BMPR-ⅡELISA Kit
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The bone morphogenetic protein (BMP) receptors belong to a family of transmembrane  serine/threonine kinases including the type I receptors BMPR1A and BMPR1B and the type II receptor  BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The  ligands of these receptors are members of the TGF-beta superfamily. Both activins and TGF-beta  transduce their signals through the formation of heteromeric complexes with 2 different types of  serine (threonine) kinase receptors. BMPRs play a crucial role during development as mutations or  deletions to the BMPR genes can cause juvenile polyposis, disrupt normal dorsal/ventral patterning  during limb development, and may be a factor in the progession of Cowden-like syndrome. Germline  mutations in the BMPR2 gene encoding bone morphogenetic protein (BMP) type II receptor (BMPR-II)  have been reported in patients with primary pulmonary hypertension (PPH).

 

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