Product name:Human Aβ1-42 ELISA Kit
Description:
Aβ is a peptide composed of 40 to 42 (43) amino acids, and is said to be cleaved out of the precursor protein APP (a protein composed of 695, 751, or 770 amino acids) by the action of β- or γ-secretase.Among the different forms of Aβ, the 42-residue fragment (Aβ1-42) readily self-associates and forms nucleation centers from where fibrils can quickly grow. The strong tendency of Aβ1-42 to aggregate is one of the reasons for the scarcity of data on its fibril formation process. Aβ1-40 is the most common form secreted from cultured cells and found in cerebro-spinal fluid (CSF). Aβ1-42 is the major component of senile plaques and considered as the most crucial factor in AD pathogenesis