Product name:Xanthine oxidase
CAS:9002-17-9
Specification:500u
Description:
Xanthine oxidase (XO (sometimes 'XAO'), a form of xanthine oxidoreductase that generates reactive oxygen species) is an enzyme that catalyzes the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. This enzyme plays an important role in the catabolism of purines in some species, including humans.
Xanthine oxidase can be converted to xanthine dehydrogenase by reversible sulfhydryl oxidation.
Xanthine oxidase is a kind of specificity is not high, can not only catalytic xanthine xanthine generated and, in turn, generated uric acid, and can direct catalytic xanthine generated uric acid enzyme, is a kind of molybdenum, the heme iron, inorganic sulfide, FAD of enzyme, found in milk, animals (especially in the case of the liver and kidney) birds, insects and bacteria.
Xanthine oxidase has a larger molecular weight, about 270,000, and contains two molecules FAD, two molybdenum atoms and eight iron atoms. Molybdenum in the enzyme exists in the form of molybdenate cofactor and is the active site of the enzyme. Iron atoms are part of the iron sulfur cluster of [2fe-2s] ferroredoxin and participate in electron transfer reactions.
Xanthine oxidase (xanthine oxidase) is a kind of flavin protease, which can catalyze the formation of uric acid from purine substrate in the body. Xanthine oxidase crystal structure has been parsed, it consists of 1330 amino acids, the amino acid sequence in the rat and has a 90% homology between people, it is made up of two perfectly symmetrical structure units, each a structural unit of 145 ku, the catalytic center includes a molybdenum poison center, two iron - sulfur and a flavin adenine dinucleotide, including molybdenum poison center is uric acid catalytic xanthine xanthine oxidase generated a key site.