Product name:Thrombin
CAS:581-64-6
Molecular Formula:C12H10ClN3S
Formula Weight:263.7459
Specification:1g
Description:
Thrombin is a sterile freeze-dried product of thrombin extracted from bovine or pig blood, which is white or quasi-white freeze-dried mass or powder. Dry powder is stored stably in 2 ~ 80C, soluble in water, 0.9% sodium chloride solution is muddy, insoluble in organic solvents. Thrombin was inactivated in aqueous solution at room temperature for 8h. Therefore, it must be prepared fresh when it is used, and the vitality of acid, alkali and metal is reduced when it is heated.
Thrombin is A protease that hydrolyzes fibrinogen into fibrin. It is composed of 308 amino acid residues and is A double-chain molecule, containing A chain and B chain. The two chains are connected by disulfide bond. Thrombin exists in animal blood, usually in the form of inactive proenzyme, which can directly act on the final link of the coagulation process, make fibrinogen become fibrin, accelerate blood coagulation, and play a role of rapid hemostasis. Ⅷ can activate blood coagulation factor, which changes the soluble fibrin difficult soluble fibrin and coagulate blood clot formation, achieve hemostasis; Can enhance coagulation factor Ⅷ and Ⅴ activity, under the participation of calcium and phospholipids, promote thrombin factor Xa, make the prothrombin into thrombin; Can promote platelet irreversible aggregation and platelet release reaction, accelerate blood coagulation; It can also promote mitosis of epithelial cells and shorten the time of wound healing by 30% ~ 50%. Therefore, thrombin is often used for hemostasis of small blood vessels, capillaries and substantial viscera with difficulty in hemostasis by ligation. It can also be used for bleeding in trauma, surgery, stomatology, otolaryngology, urology, obstetrics and gynecology, and digestive tract.