Product name:Rink-Amide resin
Molecular Formula:C30H26NO5R
Formula Weight:480.53
Specification:100g
Description:
Rink resin is originally developed for SPS of peptide amides. Now the scope of its application is extended from carboxylic amides to the immobilization of amines, substituted amides. Libaries of primary amines have been synthesized by the treatment of Rink amine resin with aldehyde to form aldimines, which are subsequently reacted with Grignard reagents or lithium reagents to yield amines that are not commercially available. Direct functionalization of Rink amide resin with nucleophiles has also been reported. The Fmoc protecting group can be readly removed with 20% piperidine in DMF prior to the above manipulation.