Product name:Nalidixic acid
CAS:389-08-2
Molecular Formula:C12H12N2O3
Formula Weight:232.24
Specification:5g
Description:
Nalidixic acid (tradenames Nevigramon, Neggram, Wintomylon and WIN-18320) is the first of the synthetic quinolone antibiotics. Technically, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridines nucleus that contains two nitrogen atoms, not quinoline, which has a single nitrogen atom.
It is especially used in treating urinary tract infections, caused, for example, by Escherichia coli, Proteus, Shigella, Enterobacter, and Klebsiella.. It is also a tool in studies as a regulation of bacterial division. It selectively and reversibly blocks DNA replication in susceptible bacteria. Nalidixic acid and related antibiotics inhibit a subunit of DNA gyrase and induce formation of relaxation complex analogue. It also inhibits the nicking dosing activity on the subunit of DNA gyrase that release the positive binding stress on the supercoiled DNA.