Product name:Methyl methanesulfonate
CAS:66-27-3
Molecular Formula:C2H6O3S
Formula Weight:110.13
Specification:100ml
Description:
Methyl methanesulfonate (MMS) is an alkylating agent and a carcinogen. It is also a suspected reproductive toxicant, and may also be a skin/sense organ toxicant.It is used in cancer treatment.
MMS methylates DNA on N7-deoxyguanine and N3-deoxyadenine. Originally, this action was believed to directly cause double-stranded DNA breaks, because homologous recombination-deficient cells are particularly vulnerable to the effects of MMS.However, it is now believed that MMS stalls replication forks, and cells that are homologous recombination-deficient have difficulty repairing the damaged replication forks.