Product name:Guanidine hydrochloride
CAS:50-01-1
Molecular Formula:CH6ClN3
Formula Weight:95.53
Specification:100g
Description:
Guanidinium chloride or guanidine hydrochloride, sometimes abbreviated GndCl, is the hydrochloride salt of guanidine.
Guanidinium chloride is one of the strongest denaturants used in physiochemical studies of protein folding. In 6 molar guanidinium chloride solution, all proteins with well ordered structure lose it, and most of them become randomly coiled, i.e. they do not contain any residual structure. However, at concentrations in the millimolar range in vivo, proteins are shown to change conformation from the prion to non-prion state. This change requires a switch from a beta-sheet based structure to a alpha-helix based structure.