Product name:Doxorubicin HCL
CAS: 246-818-3
Molecular Formula: C27H30ClNO11.HCL
Molecular Weight: 579.9802
Product description:Doxorubicin HCL is an orange needle-like crystal with melting point of 204-205℃. Soluble in water and alcohol, insoluble in acetone, benzene, chloroform, ether.
Doxorubicin HCL by embedding and inhibit polymer biosynthesis interact with DNA, inhibit XieChao helical DNA topoisomerase Ⅱ. Doxorubicin HCL prevents the DNA double helix from closing, thereby destroying the replication of the DNA strand. By embedding, Doxorubicin HCL also ACTS on transcriptionally active chromatin, causing histone changes. The results showed that the DNA damage response, epigenome and transcriptome were not controlled in the cells affected by Doxorubicin HCL.
Doxorubicin HCL is a non-periodic anti-tumor drug with a broad anti-tumor spectrum. It can be clinically used in a variety of cancers such as breast cancer, lung cancer, lymphoma and ovarian cancer. As a second-line anti-tumor drug, Doxorubicin HCL can be used for treatment when drug resistance is the first choice.