Product name:Cocarboxylase
CAS:154-87-0
Specification:1g
Description:
Cocarboxylase is a white crystalline powder. Dry product is stable, aqueous solution is not stable. Mp238-240℃ has the maximum absorption at the wavelength of 242nm. Cocarboxylase is readily soluble in water and acidic in aqueous solutions. Insoluble in ethanol, acetone and ether.
Cocarboxylase is prepared by hydrolysis of rice bran or yeast. There are many methods of synthesis. It can be prepared from 4-amino-2-methyl-5-acetylpyrimidine by hydrolysis, addition condensation, cyclization hydrolysis, oxidation, replacement and other steps. ; Acetamidine and alpha - dimethyl methyl oxygen - beta - methoxyl acrylic nitrile under the effect of sodium alcoholate, generated by condensation, hydrolysis of pyrimidine derivatives, which react with carbon dioxide, ammonia, and acetic acid - gamma chlorinated - delta - acetyl propylene carbonate acid hydrolysis and condensation, cyclization glucosinolates sulphur amine hydrochloride, the ammonia neutralization, oxidation of hydrogen peroxide, ammonium nitrate into thiamine mononitrate, finally with hydrochloric acid was prepared. ; Vitamin B1 is naturally found in rice bran, bran, lean meat, peanuts and other foods. Pure products are usually prepared by chemical synthesis. Excessive acetamidine hydrochloride was condensed into 3, 6-dimethyl-1, 2-dihydro-2, 4, 5, 7-tetraazinaphthalene in alkaline medium (methanol and sodium methoxide), and then hydrolyzed to 2-methyl-4-amino5-aminomacyrimidine under alkaline conditions. Then it ACTS with carbon disulfide and ammonia water, and then condenses with acetic acid-gamma-chloro-gamma-acetylpropyl ester, hydrolyzes and synthesizes thiothiamine hydrochloride in hydrochloric acid at 75 ~ 78℃, and finally neutralizes with ammonia water, oxidizes with hydrogen peroxide and acidifies hydrochloric acid to get thiothiamine hydrochloride.