Product name:Adenosine
CAS:58-61-7
Molecular Formula:C10H13N5O4
Formula Weight:267.24
Specification:5g
Description:
Adenosine is an active substance with the basic structure of nucleoside and purine. It is a nucleoside formed by adenine by binding d-ribose through the beta-glycoside bond. It exists widely in all types of cells. Adenosine phosphates such as ATP are important energy carriers in biochemical reactions.
Adenosine, as a natural nucleotide, is an intermediate product of metabolism in the body and one of the important active components in the body. It works by activating adenosine receptors (A receptors). In the atrial, sinus and atrioventricular nodes, adenosine activates G protein-coupled potassium channels by binding to A receptors, increasing K+ outflow and reducing autonomic capacity due to membrane hyperpolarization. It still can increase cGMP level apparently, lengthen the ERP of atrioventricular knot and decelerate conduction, restrain sympathetic nerve or be caused by isoproterenol after early, after late divide pole and exert effect to fight arrhythmia. This product is temporarily not classified in class Ⅰ ~ Ⅳ anti-arrhythmic drugs.
Adenosine is an inhibitory neuromodulator of the central nervous system that provides a balance between the brain's energy storage and energy needs. Under normal conditions, the extracellular adenosine concentration was maintained at 40 ~ 400nmoL. When ischemia and hypoxia occur, both glucose and glycogen accelerate the decomposition of ATP in response to energy demand, which then degrades, sharply increasing the level of adenosine in cells and releasing it to play its regulatory role outside cells. During the hypoxia recovery stage, endogenous adenosine, as a precursor of ATP synthesis, can regenerate into ATP under the catalysis of adenosine kinase (AK), so as to prolong the survival time of cells.
Adenosine can dilate coronary arteries and reduce myocardial contractile force. Clinically suitable for the treatment of angina pectoris, hypertension, cerebrovascular disorders, sequelae of stroke, progressive muscular atrophy, etc. Intravenous injection was used for the treatment of supraventricular tachycardia and 201Tl myocardial imaging.