Product name:High Quality Pimecrolimus
CAS:137071-32-0
Molecular Formula: C43H68ClNO11
Molecular Weight:810.45
Sponsor: Novartis Pharmaceuticals Australia
Speciality:In a pig model of allergic contact dermatitis, topical overlooks the effect of therapy with potent corticosteroids. Unlike corticosteroids, pyrazole beauty therapy do not cause the pig skin atrophy, also does not affect rat skin of langerhan cells.
Product description:Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations.