Roxithromycin is a new generation of macrolide antibiotics, mainly used for Gram-positive bacteria, anaerobic bacteria, chlamydia and mycoplasma. Its in vitro antibacterial effect is similar to that of erythromycin, and its effect in vivo is 1-4 times stronger than that of erythromycin. Roxithromycin pharmacological effects and indications:
1. Strong killing effect on Gram-negative bacteria, some Gram-negative bacteria (meningococcal, Neisseria gonorrhoeae, Influenza, Pertussis, Brucella) and spirochetes, Mycoplasma pneumoniae, Rickettsia, Legionella is sensitive and has an enhanced effect on mycoplasma and chlamydia.
2, antibacterial mechanism: combined with the bacterial control protein 50S subunit, through the inhibition of transpeptide action and MRNA displacement, inhibition of protein synthesis.
3, the product is well absorbed orally, quick effect, bioavailability and blood drug concentration are stronger than erythromycin. According to reports, the peak concentration of 150 mg of blood is as high as 6.6-7.9 ug/ml, and the erythromycin is only 0.2-0.4 ug/ml under the same conditions; roxithromycin is mainly distributed in body fluids and tissues, with high and long-lasting tissue. Concentration and cell concentration, while the half-life is as long as 12h, while erythromycin is only 1.5 to 2.0h.
4. It is the first choice drug for drug-resistant Staphylococcus aureus and hemolytic streptococcus in medical clinic. Veterinary clinic is used to treat serious infections caused by penicillin-resistant and Staphylococcus aureus, pneumonia, metritis, and chronic respiratory diseases of birds. Wait.
5, Roxithromycin is mainly used for the treatment of chronic respiratory diseases of livestock and poultry, staphylococcus and streptococcal diseases, chlamydia, spirochetes (swine dysentery), infectious pleurisy, rhinitis, etc.
6, indications are: avian neck swelling, local heat, pain, difficulty breathing, mouth and nose white foam, mucous membranes and skin blemishes and other symptoms.
What are the uses of Roxithromycin
