Erythromycin is an alkaline antibiotic extracted from the culture of red Streptomyces. In the purification, the characteristics of dissolving in different solvents in different pH are utilized, and the extraction is repeated with butyl acetate and aqueous solution to achieve the purpose of concentration and purification, and finally freeze-crystallization in butyl acetate solution to obtain erythromycin base.
Erythromycin is a macrolide antibiotic with an antibacterial spectrum similar to penicillin. For Gram-positive bacteria such as Staphylococcus, Streptococcus pyogenes, Streptococcus mutans, Streptococcus pneumoniae, Streptococcus faecalis, Streptococcus hemolyticus, Clostridium spores Bacillus, diphtheria, and Bacillus anthracis have strong inhibitory effects. Erythromycin also has a certain inhibitory effect on Gram-negative bacteria such as Neisseria gonorrhoeae, Helicobacter, Bordetella, Brucella, Legionella, Meningococcus, Haemophilus influenzae, Bacteroides, Some Shigella and Escherichia coli. In addition, it has an inhibitory effect on mycoplasma, actinomycetes, spirochetes, rickettsia, chlamydia, nocardia, a few mycobacteria, and amoeba. Staphylococcus and Staphylococcus bacteria such as Staphylococcus aureus are susceptible to this product. It is characterized by a strain that is resistant to penicillin and is sensitive to the product. The mechanism of action is mainly combined with the 50S subunit of ribonucleoprotein, inhibiting peptide acyltransferase, affecting the translocation process of ribonucleoprotein, impeding the growth of peptide chain, inhibiting the synthesis of bacterial proteins, and acting as a bacteriostatic agent.
Erythromycin production method and use
