1. Holo-transferrin complex transports iron to the normal growth and development of iron-containing tissue cells with blood circulation. Holo-transferrin is widely expressed in human body, but the expression level is significantly different, which also makes the endocytosis inconsistent. The purpose of treatment.
2. With the increasing number of cancer patients, many metal drugs with weak radioactivity are widely used in the diagnosis and treatment of cancer, such as titanium, which is mainly transported through the Holo-transferrin-mediated pathway, and Holo-transferrin can be increased. Can facilitate their absorption and transportation.
3. There is a large amount of Holo-transferrin on the surface of tumor cells, and the drug-Holo-transferrin complex is stable in plasma, which can prolong the half-life of the drug in plasma and control the release rate of the drug from the complex, so use Holo-transferrin Targeted transport of drugs is important.
4. Holo-transferrin has a special role in the transportation of brain drugs. Due to the hypotonicity of blood-brain barrier brain capillary endothelial cells to drugs, the treatment of drugs into the human brain is strictly restricted, but in the brain capillary endothelial cells. There is a specific receptor-mediated transport mechanism on which a drug can be transported into the brain via Holo-transferrin.
What are the functions of Holo-transferrin
