Amikacin disulfate salt is an aminoglycoside antibiotic. Amikacin disulfate salt for most Enterobacteriaceae bacteria, such as Escherichia coli, Klebsiella, Enterobacter, Proteus, Shigella, Salmonella, Citrobacter, Serratia, etc. They all have good effects, and also have good effects on Pseudomonas aeruginosa and other Pseudomonas, Acinetobacter, and Alcaligenes; for Neisseria meningitidis, Neisseria gonorrhoeae, Haemophilus influenzae, Yersinia, Campylobacter fetus, Mycobacterium tuberculosis and certain non-tuberculous Mycobacteria also have good antibacterial activity, and their antibacterial activity is slightly lower than that of gentamicin. The most prominent advantage of this product is that it is stable to the aminoglycoside inactivating enzymes produced by many intestinal Gram-negative bacilli, and does not lose the antibacterial activity for the passivation of such enzymes. Among the 12 inactivated enzymes currently isolated, Amikacin disulfate salt can only be inactivated by AAC (6'), and AAD (4') and APH(3')-III can cause bacteria in this product. Degree of resistance. About 60% to 70% of clinically isolated Enterobacteriaceae bacteria resistant to aminoglycosides such as gentamicin, tobramycin and netilmicin are still sensitive to this product. In recent years, there have been an increase in amikacin-resistant strains in Gram-negative bacilli.
In Gram-positive cocci, this product has a good antibacterial effect on methicillin-sensitive strains in Staphylococcus, and Streptococcus pneumoniae, Streptococcus and Enterococcus are mostly resistant to it. Amikacin disulfate salt is not effective against anaerobic bacteria.
Amikacin disulfate salt acts on the 30S subunit of bacterial ribosomes and inhibits bacterial synthesis of proteins. Amikacin is often synergistically antibacterial with semisynthetic penicillins or cephalosporins.
Pharmacological action of Amikacin disulfate salt
