Sulfamethoxazole is a white crystalline powder, odorless and slightly bitter. Almost insoluble in water; soluble in dilute hydrochloric acid, sodium hydroxide or ammonia solution. Sulfamethoxazole is mainly used for urinary tract infection, respiratory system infection, intestinal infection, biliary tract infection and local soft tissue or wound infection caused by sensitive bacteria.
Sulfamethoxazole is degraded from 5-methyl isoxazole-3-formamide under the action of sodium hypochlorite, and then condensated with p-acetamidobenzosulfonyl chloride to form 3-(p-acetamidobenzosulfonamide) -5-methyl isoxazole, which is hydrolyzed to 3-(p-aminobenzene sulfonyl amino) -5-methyl isoxazole under alkaline conditions. Isooxazole.
Sulfamethoxazole has broad antimicrobial spectrum and strong antimicrobial activity. It is especially effective against Staphylococcus and Escherichia coli. It is suitable for respiratory system, urinary system and intestinal infection. It can inhibit the growth of bacteria, especially Staphylococcus and Escherichia coli. Mainly used in the treatment of fowl cholera and so on.