D-arabinitol is obtained by degradation and oxidation of calcium gluconate.
Calcium gluconate and water are heated and dissolved together, and an iron catalyst mixed with a solution of barium acetate and iron sulfate is added. The temperature was raised to 95 ° C with stirring, and the precipitate was filtered off. The supernatant was oxidized by adding hydrogen peroxide at 40 ° C, the reaction temperature did not exceed 56 ° C, and the reaction was carried out for half an hour. After the reaction solution turned black, it was allowed to stand for half an hour, and the temperature was lowered to 40 ° C, and then hydrogen peroxide was added thereto, followed by oxidation by the above method. After half an hour, oxalic acid was added and filtered to remove calcium oxalate. The filtrate was concentrated in vacuo to a syrup and the temperature did not exceed 48 °C. Dissolve in anhydrous methanol, let cool crystallize, and filter. The filter cake was washed with methanol and dried to give a crude D-arabinitol. The crude product was recrystallized from methanol to give D(-)-glycosaldehyde.
In another method, calcium gluconate and iron gluconate are oxidized together with hydrogen peroxide, and the reactant is filtered and treated with a strong acid styrene cation exchange resin and a strongly basic quaternary ammonium type I anion exchange resin to obtain D-arabinitol.
D-arabinitol production method
