Cyclosporin A is a lipophilic cyclic peptide compound isolated from the culture of certain filamentous fungi such as Pseudomonas fluorescens and S. cerevisiae. It has been used as an immunosuppressant in the 1980s worldwide. Widely used, it is now used in the treatment of various tissues and organ transplants to prevent rejection and immune diseases.
Cyclosporin A is a potent immunosuppressive agent that inhibits the onset of cellular mediators, reversibly inhibits T cell proliferation, does not inhibit the production of blood cells, and does not affect phagocytic function, so it is comparable to other inhibitors. The advantage of less induced or aggravated infection, clinically used mainly for renal, liver, heart, lung, bone marrow transplantation anti-rejection reaction, can be combined with adrenal cortex hormones, but not with other immunosuppressive agents. Cyclosporin A is also used in certain autoimmune diseases (such as systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, autoimmune hemolytic anemia). Trial in uveitis, severe aplastic anemia, refractory primary thrombocytopenic purpura, psoriasis, etc.
Cyclosporin A is an immunosuppressant
