Application of Sulfamethazine: 1. It is used to prevent and treat staphylococci and dissolved streptococcus infection, and has inhibitory effect on bacteria such as hemolytic streptococcus and pleurisy cocci. It is mainly used to treat avian cholera, avian typhoid fever, coccidiosis of chicken and so on.
An antibacterial sulfanilamide; Induced CYP3A4 expression and acetylation by n-acetyltransferase; It shows sex-dependent pharmacokinetics, which produces metabolic changes through male specific homologous isomer CYP2C11. Inhibition of dihydrofolate synthetase to achieve the effect of blocking folate synthesis.
3, hemolytic streptococcus, pneumococcus and meningitis bacteria have inhibitory effect.
Note: long-term continuous feeding of Sulfamethazine can cause severe toxic reactions, such as hemorrhagic infarction and swelling of spleen in chickens after 8 days of continuous feeding at 0.5% concentration. Continuous feeding at 1% concentration for 3 days not only significantly affects weight gain, but also causes prolonged coagulation time and even bleeding lesions due to obstructed synthesis of intestinal vitamin K. Therefore, intermittent administration is recommended for Sulfamethazine.