2,2'-Azobis(2-methylpropionitrile) is a particularly excellent free-radical initiator. When heated to about 70 °C, it will liberate nitrogen and generate free radicals (CH3)2CCN. The free radicals are affected by cyano groups. More stable. 2,2'-Azobis(2-methylpropionitrile) can react with another organic substrate to form a new free radical while quenching itself, thereby initiating a chain reaction of free radicals (see free radical reaction). At the same time, it can also be coupled in two molecules to form a highly toxic tetramethylsuccinonitrile (TMSN).
When 2,2'-Azobis(2-methylpropionitrile) is heated to 100-107 ° C, it melts and undergoes rapid decomposition, releasing nitrogen and several organic nitrile compounds which are toxic to human body, and may cause explosion and fire. Slowly decompose at room temperature and should be stored below 10 °C. Keep away from fire and heat. poisonous. It is metabolized into hydrocyanic acid in tissues such as blood, liver, and brain of animals.